Zhang R, Jiang D, Li Z
Changhai Hospital, Shanghai.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1995;30(3):163-5.
This paper reported the clinical effects and therapeutic mechanism of blocking agent of substance P(SP) nerves on prerennial allergic rhinitis. We applied capsaicin (CAP) in the treatment of 50 cases of perennial allergic rhinitis once a week and 4 times as a therapeutic course. By using highly specific and highly sensitive SP radioimmunoassay, the SP contents in nasal secretions were determined before and after CAP therapy. The results showed that clinical symptoms of allergic rhinitis were obviously relieved and SP content in the nasal secretions was remarkably reduced from 29.444 +/- 14.280pmol/L before CAP therapy to 16.848 +/- 10.622 pmol/L after therapy (P < 0.001). Of the 50 cases, 35 cases (70.0%) showed the best effects, 12 cases (24.0%) better effects and 3 cases (6.0%) no effects. The total effective rate was 94.0%. The study indicated that therapeutic mechanism of CAP on perennial allergic rhinitis is related to the reducing of SP and the blocking of axonal reflex of the SP nerves.
本文报道了P物质（SP）神经阻滞剂对常年性变应性鼻炎的临床疗效及治疗机制。我们应用辣椒素（CAP）治疗50例常年性变应性鼻炎患者，每周1次，共4次为一个疗程。采用高特异性、高灵敏度的SP放射免疫分析法，测定CAP治疗前后鼻分泌物中SP的含量。结果显示，变应性鼻炎的临床症状明显缓解，鼻分泌物中SP含量显著降低，由CAP治疗前的29.444±14.280pmol/L降至治疗后的16.848±10.622pmol/L（P<0.001）。50例患者中，35例（70.0%）效果最佳，12例（24.0%）效果较好，3例（6.0%）无效。总有效率为94.0%。研究表明，CAP治疗常年性变应性鼻炎的机制与降低SP含量及阻断SP神经的轴突反射有关。
