关于多巴胺相关化合物在神经分泌突触处的作用。
On the actions of compounds related to dopamine at a neurosecretory synapse.
作者信息
Ginsborg B L, Turnbull K W, House C R
出版信息
Br J Pharmacol. 1976 May;57(1):133-40. doi: 10.1111/j.1476-5381.1976.tb07663.x.
Abstract
1 The effects of a number of substances related to dopamine, including all its methylated derivatives, were investigated on the membrane potential and response to nerve stimulation of cockroach salivary gland cells. 2 Only N-methyldopamine (epinine), N,N-dimethyldopamine and N,N-dimethylnoradrenaline, all with unsubstituted hydroxyl groups, directly resembled dopamine in producing a hyperpolarization which could be as large as that caused by maximal nerve stimulation. During the continued presence of these substances the hyperpolarization waned and responses to nerve stimulation declined. 3 Many of the compounds caused one or both of two other effects, namely an increase in the rate of 'spontaneous miniature hyperpolarizations' and an enhancement of the submaximal responses to single nerve stimuli. There were no obvious structural requirements for these effects.
摘要
- 研究了多种与多巴胺相关的物质，包括其所有甲基化衍生物，对蟑螂唾液腺细胞的膜电位及对神经刺激的反应的影响。2. 只有N - 甲基多巴胺（去甲肾上腺素）、N，N - 二甲基多巴胺和N，N - 二甲基去甲肾上腺素，所有这些都带有未被取代的羟基，在产生超极化方面与多巴胺直接相似，这种超极化可能与最大神经刺激所引起的超极化一样大。在这些物质持续存在期间，超极化减弱，对神经刺激的反应下降。3. 许多化合物产生了另外两种效应中的一种或两种，即“自发微小超极化”速率增加和对单个神经刺激的次最大反应增强。这些效应没有明显的结构要求。
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