关于5-羟色胺参与苯丙胺或反苯环丙胺加左旋多巴所产生的运动活动的证据。
Evidence concerning the involvement of 5-hydroxytryptamine in the locomotor activity produced by amphetamine or tranylcypromine plus L-DOPA.
作者信息
Green A R, Kelly P H
出版信息
Br J Pharmacol. 1976 May;57(1):141-7. doi: 10.1111/j.1476-5381.1976.tb07664.x.
Abstract
1 Pretreatment of rats with p-chlorophenylalanine (PCPA; 2 X 200 mg/kg) decreased the concentration of 5-hydroxytryptamine (5-HT) in the brain. It also decreased the locomotor activity produced by tranylcypromine plus L-DOPA administration 24 h after the second dose of PCPA. 2 Pretreatment with p-chloroamphetamine, which produced a similar decrease in brain 5-HT concentrations did not decrease the locomotor response to tranylcypromine and L-DOPA. 3 PCPA pretreatment decreased the rise in the concentration of DOPA and dopamine in the brain following tranylcypromine and L-DOPA, suggesting its effect on the dopamine-induced locomotor activity was the result of this drug diminishing dopamine formation in the brain, probably by inhibiting L-DOPA uptake. 4 The locomotor activity produced by tranylcypromine and L-DOPA was not decreased by pretreatment 6 h earlier with disulfiram (400 mg/kg). This argues against the locomotor activity being due to noradrenergic stimulation. 5 PCPA pretreatment did not alter amphetamine-induced stereotypy or the circling behaviour in unilateral nigro-striatal lesioned rats.
摘要
- 用对氯苯丙氨酸（PCPA；2×200毫克/千克）对大鼠进行预处理，可降低大脑中5-羟色胺（5-HT）的浓度。它还降低了在第二次给予PCPA 24小时后，反苯环丙胺加左旋多巴给药所产生的运动活性。2. 用对氯苯丙胺进行预处理，其使大脑中5-HT浓度产生类似降低，但并未降低对反苯环丙胺和左旋多巴的运动反应。3. PCPA预处理降低了反苯环丙胺和左旋多巴给药后大脑中多巴和多巴胺浓度的升高，这表明其对多巴胺诱导的运动活性的影响是该药物减少大脑中多巴胺形成的结果，可能是通过抑制左旋多巴摄取。4. 提前6小时用双硫仑（400毫克/千克）进行预处理，并未降低反苯环丙胺和左旋多巴所产生的运动活性。这反驳了运动活性是由去甲肾上腺素能刺激引起的观点。5. PCPA预处理并未改变苯丙胺诱导的刻板行为或单侧黑质-纹状体损伤大鼠的转圈行为。
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