去甲丙咪嗪对神经元对三甲氧苯乙胺反应的增强作用。
Potentiation by desipramine of neuronal responses to mescaline.
作者信息
Bevan P, Bradshaw C M, Szabadi E
出版信息
Br J Pharmacol. 1976 May;57(1):152-4. doi: 10.1111/j.1476-5381.1976.tb07666.x.
Abstract
The effect of desipramine on responses of single cortical neurones to mescaline was studied by the microelectrophoretic technique. Both potentiation and antagonism of responses to mescaline by desipramine were observed. The antagonism may be related to the alpha-adrenolytic action of desipramine. The potentiation is unlikely to reflect the uptake blocking action of desipramine, since desipramine does not block the uptake of mescaline in the cerebral cortex. It is suggested that the potentiation may be due to a post-synaptic action of desipramine.
摘要
采用微电泳技术研究了去甲丙咪嗪对单个皮层神经元对三甲氧苯乙胺反应的影响。观察到去甲丙咪嗪对三甲氧苯乙胺反应既有增强作用又有拮抗作用。这种拮抗作用可能与去甲丙咪嗪的α-肾上腺素能阻断作用有关。增强作用不太可能反映去甲丙咪嗪的摄取阻断作用，因为去甲丙咪嗪并不阻断大脑皮层中三甲氧苯乙胺的摄取。有人提出，增强作用可能是由于去甲丙咪嗪的突触后作用所致。
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