三甲氧苯乙胺对单个皮质神经元的作用。
Effect of mescaline on single cortical neurones.
作者信息
Bradshaw C M, Roberts M H, Szabadi E
出版信息
Br J Pharmacol. 1971 Dec;43(4):871-3. doi: 10.1111/j.1476-5381.1971.tb07225.x.
The effects of mescaline upon single cortical neurones were studied, using the microiontophoretic technique. Mescaline elicited excitatory and depressant responses similar to those evoked by noradrenaline (NA) and 5-hydroxytryptamine (5-HI). The responses to NA and mescaline were usually in the same direction, the neurone being either excited by both drugs or depressed by both drugs. The correlation between the effects of mescaline and 5-HT, however, was less consistent. The beta-adrenoceptor blocking agent MJ-1999 and the 5-HT antagonist methysergide were both effective in antagonizing mescaline responses.
采用微离子电泳技术研究了三甲氧苯乙胺对单个皮层神经元的作用。三甲氧苯乙胺引发的兴奋和抑制反应类似于去甲肾上腺素（NA）和5-羟色胺（5-HT）所引发的反应。对NA和三甲氧苯乙胺的反应通常方向相同，神经元要么被这两种药物都兴奋，要么都被抑制。然而，三甲氧苯乙胺和5-HT作用之间的相关性不太一致。β-肾上腺素能受体阻断剂MJ-1999和5-HT拮抗剂甲基麦角新碱都能有效拮抗三甲氧苯乙胺的反应。
Zotero 插件