Kania Artur, Jessell Thomas M
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.
Neuron. 2003 May 22;38(4):581-96. doi: 10.1016/s0896-6273(03)00292-7.
The formation of topographic neural maps relies on the coordinate assignment of neuronal cell body position and axonal trajectory. The projection of motor neurons of the lateral motor column (LMC) along the dorsoventral axis of the limb mesenchyme constitutes a simple topographic map that is organized in a binary manner. We show that LIM homeodomain proteins establish motor neuron topography by coordinating the mediolateral settling position of motor neurons within the LMC with the dorsoventral selection of axon pathways in the limb. These topographic projections are established, in part, through LIM homeodomain protein control of EphA receptors and ephrin-A ligands in motor neurons and limb mesenchymal cells.
地形神经图谱的形成依赖于神经元细胞体位置和轴突轨迹的坐标分配。外侧运动柱（LMC）的运动神经元沿肢体间充质的背腹轴投射，构成了一个以二元方式组织的简单地形图谱。我们发现，LIM同源结构域蛋白通过协调LMC内运动神经元的内外侧定居位置与肢体中轴突通路的背腹选择，来建立运动神经元的地形结构。这些地形投射部分是通过LIM同源结构域蛋白对运动神经元和肢体间充质细胞中EphA受体和ephrin-A配体的控制而建立的。
