Oksbjerg Dalton Susanne, Munk Laursen Thomas, Mellemkjaer Lene, Johansen Christoffer, Mortensen Preben B
Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100, Copenhagen, Denmark.
Schizophr Res. 2003 Jul 1;62(1-2):89-92. doi: 10.1016/s0920-9964(02)00430-9.
The authors investigated the risk for breast cancer in schizophrenia in a cohort of 1336313 Danish women born after 1935, including information on reproductive factors. In all, 7541 had been hospitalized for schizophrenia in 1970-1997 and the overall relative risk for breast cancer adjusted for age, period, age at first birth and number of births was not increased (RR, 0.91; 95% confidence interval, 0.71-1.12). Studies not taking parity into account may overestimate the risk for breast cancer in schizophrenic women.
作者对1935年以后出生的1336313名丹麦女性队列中的精神分裂症患者患乳腺癌的风险进行了调查，其中包括生殖因素信息。1970年至1997年期间，共有7541人因精神分裂症住院，调整年龄、时期、初产年龄和生育次数后，患乳腺癌的总体相对风险并未增加（相对风险，0.91；95%置信区间，0.71 - 1.12）。未考虑生育情况的研究可能高估了精神分裂症女性患乳腺癌的风险。
