Fiskerstrand Eli Janne, Svaasand Lars O, Nelson J Stuart
Center for Esthetic Laser Surgery, NO-7010 Trondheim, Norway.
Lasers Surg Med. 2003;32(5):399-404. doi: 10.1002/lsm.10175.
The aim was to study hair removal efficacy, and possible side effects of two commercially available long pulsed diode lasers. The radiant exposure was selected to a value of 35 J/cm2, which is frequently used in the clinic in accordance with manufacturer's recommendations.
STUDY DESIGN/MATERIALS AND METHODS: A prospective clinical study was performed on twenty-nine patients with hair color ranging from light brown to black on the upper lip. One half of the upper lip was randomly selected for treatment with the MedioStar laser; the contralateral half of the lip was treated with the LightSheer laser. Three treatments were performed at 6-8 week intervals. Percent hair reduction and acute- and long-term side effects were evaluated after treatment.
The average hair reductions 6 months after the first treatment were 49% with the MedioStar laser and 48% with the LightSheer laser. No scarring or pigmentary change of the skin was observed after any of the treatments with either laser. However, differences in acute side effects such as degree of erythema and burned hairs were observed.
No statistically significant differences in hair removal efficacy were observed. These results agree with mathematical modeling, which also offers a method to estimate hair removal efficacy and adverse effects for a range of hair characteristics and laser parameters.
本研究旨在探讨两款市售长脉冲二极管激光的脱毛效果及可能的副作用。根据制造商的建议，选择35 J/cm2的辐照剂量，该剂量在临床上常用。
研究设计/材料与方法：对29名上唇毛发颜色从浅棕色到黑色的患者进行了一项前瞻性临床研究。随机选择上唇的一半用MedioStar激光治疗；对侧唇部用LightSheer激光治疗。每隔6 - 8周进行三次治疗。治疗后评估毛发减少百分比以及急性和长期副作用。
首次治疗6个月后，MedioStar激光的平均毛发减少率为49%，LightSheer激光为48%。两种激光治疗后均未观察到皮肤瘢痕或色素沉着变化。然而，观察到红斑程度和毛发烧灼等急性副作用存在差异。
在脱毛效果上未观察到统计学显著差异。这些结果与数学模型一致，数学模型也提供了一种方法来估计一系列毛发特征和激光参数下的脱毛效果及不良反应。
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