Khatri Khalil A
Skin & Laser Surgery Center of New England.
Dermatol Surg. 2004 Sep;30(9):1205-7; discussion 1207. doi: 10.1111/j.1524-4725.2004.30373.x.
It is generally believed that any intervention in skin while on isotretinoin or within 6 months after the treatment can lead to prolonged healing and scarring.
The objective was to evaluate the side effects of laser hair removal in patients undergoing isotretinoin treatment.
Seven female patients undergoing isotretinoin therapy for acne were treated with a diode laser with a wavelength of 810 nm, a contact-cooling device, and a variable pulse width of 50 to 1000 ms. All volunteers received first treatment in the axillary or bikini area at 21 J/cm(2) (80 W) and the second treatment was done in the same area at 24 J/cm(2) (90 W). Six volunteers received additional treatments of chin area with a fluence of 21 or 24 J/cm(2). All volunteers were evaluated and photographed 1 week and 1 month after each treatment and degree of erythema, pigmentary change, vesiculation, swelling, and scarring was documented.
There was no erythema, pigmentary change, swelling, or scarring at any follow up visits. One volunteer presented with a bulla 1 week after second treatment, which was resolved at 1-month follow-up. All volunteers were satisfied with the degree of hair removal with two treatments.
This limited study suggests that diode laser hair removal is safe in patients undergoing isotretinoin therapy.
一般认为,在服用异维甲酸期间或治疗后6个月内对皮肤进行任何干预都可能导致愈合时间延长和瘢痕形成。
评估接受异维甲酸治疗的患者进行激光脱毛的副作用。
7名接受异维甲酸治疗痤疮的女性患者接受了波长为810nm的二极管激光治疗,配备接触式冷却装置,可变脉冲宽度为50至1000毫秒。所有志愿者首先在腋窝或比基尼区域以21J/cm²(80W)进行首次治疗,第二次治疗在同一区域以24J/cm²(90W)进行。6名志愿者在下巴区域以21或24J/cm²的能量密度接受了额外治疗。每次治疗后1周和1个月对所有志愿者进行评估并拍照,记录红斑、色素变化、水疱形成、肿胀和瘢痕形成的程度。
在任何随访中均未出现红斑、色素变化、肿胀或瘢痕形成。一名志愿者在第二次治疗后1周出现水疱,在1个月随访时消退。所有志愿者对两次治疗后的脱毛程度均满意。
这项有限的研究表明,二极管激光脱毛对接受异维甲酸治疗的患者是安全的。