Erdem C Zuhal, Altin Remzi, Erdem L Oktay, Kargi Sebnem, Kart Levent, Cinar Fikret, Ayoglu Ferruh
Department of Radiology, Zonguldak Karaelmas University School of Medicine, Kozlu 67600, Zonguldak, Turkey.
J Clin Ultrasound. 2003 Jun;31(5):250-7. doi: 10.1002/jcu.10171.
We used color Doppler sonography to determine blood flow velocities in the extraocular orbital vessels of patients with obstructive sleep apnea syndrome (OSAS) and compared the results with those of healthy control subjects without OSAS.
Patients with OSAS were classified according to the apnea-hypopnea index (AHI) as having mild OSAS (AHI < 20) or severe OSAS (AHI > or = 20). The peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistance index were measured in the ophthalmic artery (OA), central retinal artery (CRA), lateral short posterior ciliary artery, and medial short posterior ciliary artery using color Doppler sonography. Only 1 eye was measured in each study participant, and right and left eyes were chosen randomly. The blood flow velocities of patients with OSAS and those of control subjects were compared with the Kruskal-Wallis test and Wilcoxon's rank-sum test.
The study comprised 30 patients (15 with mild and 15 with severe OSAS) and 20 healthy control subjects. Blood flow velocities were higher in most measured vessels in patients with OSAS than they were in the control subjects. Among patients with mild OSAS, the PSVs and EDVs in the posterior ciliary arteries were statistically significantly higher than those of the control group (p < 0.05), but those in the OA and CRA did not differ significantly between the mild OSAS group and the control group (p > 0.05). However, as the severity of OSAS increased, the PSVs and EDVs of the OA and CRA were also affected (p < 0.05).
Color Doppler sonographic measurements of blood flow parameters in the orbital vessels may differ significantly between patients with OSAS and those without the syndrome. Therefore, OSAS should be considered in addition to other conditions when interpreting the results of color Doppler sonography of the extraocular orbital vessels if the clinical history points toward such a diagnosis.
我们使用彩色多普勒超声来测定阻塞性睡眠呼吸暂停综合征（OSAS）患者眼外眶血管中的血流速度，并将结果与无OSAS的健康对照者进行比较。
根据呼吸暂停低通气指数（AHI）将OSAS患者分为轻度OSAS（AHI < 20）或重度OSAS（AHI≥20）。使用彩色多普勒超声测量眼动脉（OA）、视网膜中央动脉（CRA）、睫状后短外侧动脉和睫状后短内侧动脉的收缩期峰值速度（PSV）、舒张末期速度（EDV）和阻力指数。每位研究参与者仅测量一只眼睛，左右眼随机选择。采用Kruskal-Wallis检验和Wilcoxon秩和检验比较OSAS患者和对照者的血流速度。
该研究包括30例患者（15例轻度OSAS和15例重度OSAS）和20例健康对照者。OSAS患者大多数测量血管中的血流速度高于对照者。在轻度OSAS患者中，睫状后动脉的PSV和EDV在统计学上显著高于对照组（p < 0.05），但轻度OSAS组与对照组的OA和CRA中的PSV和EDV无显著差异（p > 0.05）。然而，随着OSAS严重程度的增加，OA和CRA的PSV和EDV也受到影响（p < 0.05）。
OSAS患者和无该综合征患者的眶血管血流参数的彩色多普勒超声测量可能存在显著差异。因此，如果临床病史指向该诊断，在解释眼外眶血管彩色多普勒超声结果时，除其他情况外还应考虑OSAS。
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