Dong Z, Guan G, Chang W
Department of Otorhinolaryngology-Head and Neck Surgery, Third Teaching Hospital of Bethune University of Medical Sciences, Changchun 130031, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2000 Dec;35(6):429-31.
To further understand the pathogenic mechanism of nasal polyps, namely the cells proliferation and apoptosis in nasal polyps tissue.
The proliferation cell nuclear antigen (PCNA), apoptosis associated gene protein (Bcl-2, Bax) were determined in 26 tissue samples of nasal polyps and 14 controls from normal inferior turbinates respectively.
(1) The positive expression e of PCNA, Bcl-2 and Bax were significantly higher in epithelium of nasal polyps than the controls, and the expression rate of Bcl-2/Bax, however, tended equipoise. (2) The expression of Bcl-2 were significantly stronger than Bax in glands, eosinophils of nasal polyps tissue, and there were not significant differences in inferior turbinates.
There is strongly proliferation activity in the epithelium of nasal polyps, and expression imbalance of Bcl-2/Bax may be one of the important factors of eosinophilia in nasal polyps tissue.
进一步了解鼻息肉的发病机制，即鼻息肉组织中的细胞增殖和凋亡情况。
分别检测26例鼻息肉组织样本和14例正常下鼻甲对照组织中的增殖细胞核抗原（PCNA）、凋亡相关基因蛋白（Bcl-2、Bax）。
（1）鼻息肉上皮中PCNA、Bcl-2和Bax的阳性表达明显高于对照组，而Bcl-2/Bax的表达率趋于平衡。（2）鼻息肉组织腺体、嗜酸性粒细胞中Bcl-2的表达明显强于Bax，下鼻甲中无明显差异。
鼻息肉上皮存在较强的增殖活性，Bcl-2/Bax表达失衡可能是鼻息肉组织嗜酸性粒细胞增多的重要因素之一。
