Jaramillo J
Can J Physiol Pharmacol. 1976 Apr;54(2):140-5. doi: 10.1139/y76-022.
Dexclamol, a potent neuroleptic, was found to potentiate the anesthetic actions of halothane when given at relatively small dose to albino rats. This effect was further enhanced by the addition of phenoperidine, a potent analgesic, at doses that per se did not influence the effects of halothane. Droperidol was used as a standard. In potentiating the effects of halothane, dexclamol behaved both qualitatively and quantitatively in a manner similar to droperidol. Dexclamol, however, was approximately 37 times less potent than droperidol in antagonizing the vasopressor effects of epinephrine.
地克麻醇是一种强效安定药，研究发现，对白化大鼠给予相对小剂量的地克麻醇时，它能增强氟烷的麻醉作用。添加强效镇痛药苯哌替啶（其本身剂量不影响氟烷的作用）可进一步增强这种效应。氟哌利多用作对照标准。在增强氟烷的作用方面，地克麻醇在定性和定量上的表现都与氟哌利多相似。然而，在拮抗肾上腺素的升压作用方面，地克麻醇的效力约比氟哌利多弱37倍。
