Jaramilio J
Br J Anaesth. 1976 Dec;48(12):1149-55. doi: 10.1093/bja/48.12.1149.
In a double-blind cross-over study in dogs, dexclamol was compared with droperidol as the neuroleptic component of a neuroleptanalgestic combination. Fentanyl was the narcotic analgessic. Neuroleptanaesthesia was induced with a mixture of the neuroleptic, the analgesic and nitrous oxide in oxygen. Dexclamol 200 microng/kg i.v. was as effective as droperidol at the same dose in inducing neurolepsy and in supplementing nitrous oxide anaesthesia. Changes in heart rate, respiratory rate and rectal temperature in the animals treated with dexclamol were not different from those observed in the animals treated with droperidol. A comparison of the adrenolytic properties of dexclamol and droperidol was made on the isolated rabbit aortic strip. Both compunds produced a parallel shift to the right of the noradrenaline cumulative dose-response curves, indicating competitive antagonism. The pA2 values showed dexclamol to be approximately 15 times less potent than droperidol in inhibiting the noradrenaline-induced contraction of the rabbit aortic strip.
在一项针对犬类的双盲交叉研究中，将右氯苯那敏与氟哌利多作为神经安定镇痛合剂中的神经安定成分进行比较。芬太尼为麻醉性镇痛药。用神经安定药、镇痛药与氧化亚氮在氧气中的混合气体诱导神经安定麻醉。静脉注射200微克/千克的右氯苯那敏在诱导神经安定及补充氧化亚氮麻醉方面与相同剂量的氟哌利多效果相当。接受右氯苯那敏治疗的动物的心率、呼吸频率及直肠温度变化与接受氟哌利多治疗的动物所观察到的变化并无差异。在离体兔主动脉条上比较了右氯苯那敏与氟哌利多的抗肾上腺素能特性。两种化合物均使去甲肾上腺素累积剂量-反应曲线平行右移，表明存在竞争性拮抗作用。pA2值显示，在抑制去甲肾上腺素诱导的兔主动脉条收缩方面，右氯苯那敏的效力约为氟哌利多的1/15。
