Salo E J, Rosengård S A, Salmi R E, Sandbacka B O, Huhtala H J
Cancer Res. 1976 Aug;36(8):2750-3.
Cancer-related changes in the serum seromucoid fraction are well known. Last year Woodman published an interesting carbocyanine dye binding method for determination of serum carbohydrate polyanions in sera of normal, traumatized, and tumor-bearing mice. The usefulness of this method for clinical practice has been investigated in this study. Carbocyanine dye-binding polyanion (CPA) and the sialidase-sensitive fraction of this polyanion (SPA) have been determined in sera of 705 human subjects including healthy normal individuals and patients suffering from a broad spectrum of malignant and nonmalignant disease states. Overall, in malignant diseases the CPA and SPA values, in mg pectin equivalents per liter (mean +/-2 S.D.) (292 +/- 111 and 135 +/- 68, respectively) were significantly higher than in the serum from normal controls (166 +/- 33; 74 +/- 18) and patients hospitalized with a variety of nonmalignant disease (195 +/- 56; 92 +/- 36). The highest CPA and SPA values were found in gynecological (331 +/- 117; 149 +/- 69), bronchial (294 +/- 72; 137 +/- 51), and gastrointestinal cancers (316 +/- 111; 154 +/- 69). Elevated CPA values were found in 59.9% and elevated SPA values in 52.8% of patients suffering from malignant diseases. Successfully, radically treated cancer patients with no detectable residues or metastases for at least 1 year had values (186 +/- 39; 76 +/-24) almost within the normal ranges (93 to 250 mg pectin equivalents per liter for CPA and 35 to 120 mg pectin equivalents per liter for SPA).
血清类粘蛋白组分中与癌症相关的变化是众所周知的。去年，伍德曼发表了一种有趣的花青染料结合法，用于测定正常、创伤及荷瘤小鼠血清中的碳水化合物多阴离子。本研究对该方法在临床实践中的实用性进行了调查。在705名人类受试者的血清中测定了花青染料结合多阴离子（CPA）及其对唾液酸酶敏感的组分（SPA），这些受试者包括健康正常个体以及患有多种恶性和非恶性疾病的患者。总体而言，在恶性疾病中，CPA和SPA值，以每升果胶当量毫克数表示（均值±2标准差）（分别为292±111和135±68）显著高于正常对照组血清（166±33；74±18）以及因各种非恶性疾病住院的患者（195±56；92±36）。在妇科癌症（331±117；149±69）、支气管癌（294±72；137±51）和胃肠道癌（316±111；154±69）中发现了最高的CPA和SPA值。在患有恶性疾病的患者中，59.9%的患者CPA值升高，52.8%的患者SPA值升高。成功接受根治性治疗且至少1年内无可检测到的残留或转移的癌症患者，其值（186±39；76±24）几乎在正常范围内（CPA为每升93至250毫克果胶当量，SPA为每升35至120毫克果胶当量）。
