Parsons R G, Longmire R L, Hoch S O, Hoch J A
Cancer Res. 1977 Mar;37(3):692-5.
A human serum DNA-binding protein (C3DP) derived from complement component C3 has been found in elevated concentrations in the sera of individuals with malignant diseases. An assay system has been devised which reveals quantitative values of serum C3DP levels. Results obtained using this system indicate that normal human sera have an average C3DP level of 242 mug/ml (range, 40 to 146), whereas sera from individuals with active carcinomas have an average C3DP level of 242 mug/ml (range, 146 to 400). Sera from individuals with active leukemias, lymphomas, and melanomas all had elevated levels of C3DP, whereas sera from individuals with polycythemia vera or other nonmalignant diseases had normal or only slightly elevated C3DP concentrations. No tissue specificity seems to be required for malignant growths to result in elevated C3DP serum concentrations. The levels of C3DP in 79% of the individuals who experienced disease remission were found to decline to normal values, concurrent with the disease regression. Patients who did not respond to therapy regimens retained high C3DP levels.
在患有恶性疾病的个体血清中，已发现一种源自补体成分C3的人血清DNA结合蛋白（C3DP）浓度升高。已设计出一种检测系统，可揭示血清C3DP水平的定量值。使用该系统获得的结果表明，正常人血清的平均C3DP水平为242微克/毫升（范围为40至146），而患有活动性癌症的个体血清的平均C3DP水平为242微克/毫升（范围为146至400）。患有活动性白血病、淋巴瘤和黑色素瘤的个体血清中C3DP水平均升高，而患有真性红细胞增多症或其他非恶性疾病的个体血清中C3DP浓度正常或仅略有升高。恶性肿瘤导致血清C3DP浓度升高似乎不需要组织特异性。在79%经历疾病缓解的个体中，C3DP水平下降至正常值，与疾病消退同时发生。对治疗方案无反应的患者C3DP水平仍然很高。
