Jones P A, Laug W E, Gardner A, Nye C A, Fink L M, Benedict W F
Cancer Res. 1976 Aug;36(8):2863-7.
Various potential in vitro correlates of malignancy were studied in four chemically transformed C3H/10T1/2 Clone 8 mouse cell lines and were compared with controls cells. The degree of tumorigenicity was best predicted by the relative plating efficiencies of the morphologically transformed cells in soft agar. All transformed cells also showed an increase in extracellular fibrinolytic activity which may be an additional marker for transformation. Intracellular fibrinolytic activity and loss of 125I-labeled cell surface protein (M.W. 250,000) were not correlated with morphological transformation or tumorigenicity in these cells.
在四种化学转化的C3H/10T1/2克隆8小鼠细胞系中研究了各种潜在的体外恶性相关因素，并与对照细胞进行了比较。通过形态转化细胞在软琼脂中的相对铺板效率可以最好地预测致瘤性程度。所有转化细胞还表现出细胞外纤溶活性增加，这可能是转化的另一个标志物。在这些细胞中，细胞内纤溶活性和125I标记的细胞表面蛋白（分子量250,000）的丢失与形态转化或致瘤性无关。
