Paré Pierre, Meyer François, Armstrong David, Pyzyk Myron, Pericak Dan, Goeree Ron
Division of Gastroenterology, Centre Hospitalier Affilié Universitaire de Québec-Hôpital St-Sacrement, 1050 Chemin Ste-Foy, Quebec City, Quebec G1S 4L8, Canada.
Can J Gastroenterol. 2003 May;17(5):307-12. doi: 10.1155/2003/530984.
Although the diagnosis of gastroesophageal reflux disease (GERD) is based primarily on symptoms experienced by a patient, relatively little attention has been paid to the development and validation of self-administered questionnaires specific to GERD symptoms. The present article presents the validation of the short, self-administered GERD Symptom Frequency Questionnaire (GSFQ).
Patients with GERD participating in a randomized clinical trial comparing pantoprazole and nizatidine were asked to complete the GSFQ together with validated instruments for measurement of health-related quality of life (Medical Outcome Study Short Form 12) and gastrointestinal symptoms (Gastrointestinal Symptom Rating Scale). Completion of the GSFQ, Medical Outcome Study Short Form 12 and Gastrointestinal Symptom Rating Scale took place upon entry into the trial (baseline) and during the trial (days 7 and 28). Endoscopy was performed at baseline and after 28 days. Cronbach alpha was used to assess the internal consistency of the questionnaire. The test-retest reliability of the GSFQ was examined by the intraclass correlation coefficient among the 36 patients with stable GERD symptoms between day 7 and day 28. Construct validity was assessed by comparing the GSFQ with previously validated instruments. Known group validity was determined by comparing GSFQ scores across groups of patients known to differ clinically. Responsiveness to change was assessed by the Guyatt's statistic.
Two hundred twenty-one patients formed the study baseline group. The analysis demonstrated that the GSFQ questionnaire had excellent psychometric properties shown by the high internal consistency (Cronbach alpha 0.84); that the test-retest reliability was satisfactory (intraclass correlation coefficient 0.64); that there was good evidence that the GSFQ indeed measured what it was intended to measure (validity); and that the GSFQ was highly responsive to change (Guyatt's statistic 1.48).
The GSFQ is a short, self-administered, easy to use, GERD-specific questionnaire which should be considered as a useful assessment tool in the evaluation of patients with GERD and in the assessment of treatment outcomes.
尽管胃食管反流病（GERD）的诊断主要基于患者的症状，但针对GERD症状的自我管理问卷的开发和验证却相对较少受到关注。本文介绍了简短的自我管理的GERD症状频率问卷（GSFQ）的验证情况。
参与泮托拉唑和尼扎替丁对比随机临床试验的GERD患者被要求完成GSFQ，以及用于测量健康相关生活质量的经过验证的工具（医学结局研究简表12）和胃肠道症状（胃肠道症状评分量表）。GSFQ、医学结局研究简表12和胃肠道症状评分量表在试验入组时（基线）以及试验期间（第7天和第28天）完成。在基线和28天后进行内镜检查。使用Cronbach α评估问卷的内部一致性。通过第7天至第28天GERD症状稳定的36例患者的组内相关系数检查GSFQ的重测信度。通过将GSFQ与先前验证的工具进行比较来评估结构效度。通过比较已知临床差异的患者组之间的GSFQ分数来确定已知组效度。使用盖亚特统计量评估对变化的反应性。
221例患者组成研究基线组。分析表明，GSFQ问卷具有出色的心理测量特性，表现为高内部一致性（Cronbach α 0.84）；重测信度令人满意（组内相关系数0.64）；有充分证据表明GSFQ确实测量了其预期测量的内容（效度）；并且GSFQ对变化具有高度反应性（盖亚特统计量1.48）。
GSFQ是一种简短、自我管理、易于使用的GERD特异性问卷，应被视为评估GERD患者和评估治疗结果的有用评估工具。
