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Analysis of urinary nucleosides. III. Identification of 5'-deoxycytidine in urine of a patient with head and neck cancer.

作者信息

Dudley Edward, Lemiere Filip, Van Dongen Walter, Langridge James I, El-Sharkawi Salah, Games David E, Esmans Eddy L, Newton Russell P

机构信息

Biochemistry Group, School of Biological Sciences, Wallace Building, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK.

出版信息

Rapid Commun Mass Spectrom. 2003;17(11):1132-6. doi: 10.1002/rcm.1034.

DOI:10.1002/rcm.1034
PMID:12772268
Abstract

Modified nucleosides in the urine have been postulated to be diagnostic indices of disease, particularly of cancer. The urine of a patient with terminal head and neck cancer has been found to contain a modified nucleoside with a protonated molecule of m/z 228. By means of high-performance liquid chromatography/ion trap mass spectrometry (HPLC/ITMS) and capillary liquid chromatography/triple quadruple mass spectrometry (CapLC/TQMS) we have identified the compound as 5'-deoxycytidine. This is the first report of 5'-deoxycytidine in man: in addition to the elucidation of its structure, its possible origins and the potential significance of its occurrence are discussed.

摘要

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