Hietanen E
Digestion. 1975;13(1-2):33-41. doi: 10.1159/000197693.
Mucosal response of alkaline phosphatase, ATPase and disaccharidase (lactase, maltase and trehalase) activities to sex hormones were studied by comparing male and female rats and castrated males and by injecting testosterone into castrated males. Alkaline phosphatase showed a very steep gradient in the small intestine from the oral to the aboral end, whereas ATPase activity in the ileum was still about 50% of that in the duodenum. Both enzymes showed only minor sex variations and weal response to castration. Lactase and maltase had peak activities in the jejunum, but trehalase activity was nearly equally high in the duodenal mucosa as in the jejunum. Jejunal lactase activity was about 50% lower in female than in male rats and castration decreased activity in males to the same low level as found in females. The administration of testosterone to castrated male rats did not enhance activity. Maltase activity showed similar sex variation, although castration was not able to decrease activity during the test period. Trehalase activity was lower in female than in male rats. The administration of testosterone enhance activity in castrated males.
通过比较雄性和雌性大鼠、去势雄性大鼠，并给去势雄性大鼠注射睾酮，研究了碱性磷酸酶、ATP酶和双糖酶（乳糖酶、麦芽糖酶和海藻糖酶）活性对性激素的黏膜反应。碱性磷酸酶在小肠中从口腔端到肛门端呈现出非常陡峭的梯度，而回肠中的ATP酶活性仍约为十二指肠中的50%。这两种酶仅表现出微小的性别差异以及对去势的微弱反应。乳糖酶和麦芽糖酶在空肠中具有最高活性，但海藻糖酶在十二指肠黏膜中的活性与在空肠中几乎一样高。雌性大鼠空肠中的乳糖酶活性比雄性大鼠低约50%，去势使雄性大鼠的活性降低到与雌性大鼠相同的低水平。给去势雄性大鼠注射睾酮并不能提高其活性。麦芽糖酶活性表现出类似的性别差异，尽管在测试期间去势并不能降低其活性。雌性大鼠中的海藻糖酶活性低于雄性大鼠。给去势雄性大鼠注射睾酮可提高其活性。
