Asp N G, Gudmand-Höyer E, Andersen B, Berg N O, Dahlqvist A
Scand J Gastroenterol. 1975;10(6):647-51.
The longitudinal distribution of various enzymes along the human small intestine was studied by analysis of biopsies from different parts of the small intestine, obtained from 13 patients during shunt-operation for severe obesity. Alkaline phosphatase and 3 glycolytic enzyme activities studied were rather uniformly distributed along the small intestine. Acid beta-galactosidase and hetero beta-galactosidase activities were highest in the proximal small intestine with a gradual decline throughout the intestine. The activity in the distal ileum was about half of the maximum activity. Maltase, isomaltase, sucrase, and trehalase activity had a broad maximum in the proximal and middle small intestine with a rather sharp decrease in the distal ileum. Lactase activity had a more pronounced maximum in the middle intestine with a pronounced decrease towards the proximal and distal ends. The disaccharidase activities in surgical biopsies taken 5 cm distal to the ligament of Treitz were about 10% higher than in peroral biopsies taken just at the ligament.
通过对13例重度肥胖患者在分流手术期间从小肠不同部位获取的活检组织进行分析，研究了各种酶在人小肠中的纵向分布。所研究的碱性磷酸酶和3种糖酵解酶活性在小肠中分布较为均匀。酸性β-半乳糖苷酶和杂合β-半乳糖苷酶活性在小肠近端最高，在整个肠道中逐渐下降。回肠末端的活性约为最大活性的一半。麦芽糖酶、异麦芽糖酶、蔗糖酶和海藻糖酶活性在小肠近端和中部有一个较宽的最大值，在回肠末端急剧下降。在Treitz韧带远端5 cm处获取的手术活检组织中的双糖酶活性比在Treitz韧带处获取的经口活检组织中的双糖酶活性高约10%。
