苄环烷未能影响大鼠纹状体酪氨酸羟化酶的活性。
Failure of benzoctamine to influence the activity of rat striatum tyrosine-hydroxylase.
作者信息
Coelle E F, Osborne N N, Neuhoff V, Sontag K H
出版信息
Arzneimittelforschung. 1976;26(8):1630-1.
PMID:12774
Abstract
The influence of benzoctamine (Tacitin) on rat striatum tyrosine-hydroxylase was analized. Injection of 100 mg benzoctamine/kg body weight caused no alteration in the tyrosine-hydroxylase activity whilst a decrease of about 60% in the activity was recorded after treatment with a-methyl-p-tyrosine a known inhibitor of tyrosine-hydroxylase. The present results differ from those of Maitre et al. which indicated that benzoctamine inhibited tyrosine-hydroxylase activity.
摘要
分析了苄非他明（Tacitin）对大鼠纹状体酪氨酸羟化酶的影响。注射100毫克苄非他明/千克体重对酪氨酸羟化酶活性没有影响，而在用已知的酪氨酸羟化酶抑制剂α-甲基对酪氨酸处理后，该酶活性下降了约60%。目前的结果与梅特尔等人的结果不同，他们的结果表明苄非他明抑制酪氨酸羟化酶活性。
Zotero 插件