Vincent Michael S, Gumperz Jenny E, Brenner Michael B
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, One Jimmy Fund Way, Boston, Massachusetts 02115, USA.
Nat Immunol. 2003 Jun;4(6):517-23. doi: 10.1038/ni0603-517.
CD1 molecules bind foreign lipid antigens as they survey the endosomal compartments of infected antigen-presenting cells. Unlike T cells that recognize CD1-restricted foreign lipids, CD1-restricted T cells that are self-antigen-reactive function as 'auto-effectors' that are rapidly stimulated to carry out helper and effector functions upon interaction with CD1-expressing antigen-presenting cells. The functional distinctions between subsets of CD1-restricted T cells, and the pathways by which these cells both influence the inflammatory and tolerogenic effects of dendritic cells and activate natural killer cells and other lymphocytes, provide insight into how CD1-restricted T cells regulate antimicrobial responses, antitumor immunity and the balance between tolerance and autoimmunity.
CD1分子在巡查被感染的抗原呈递细胞的内体区室时会结合外来脂质抗原。与识别受CD1限制的外来脂质的T细胞不同，具有自身抗原反应性的受CD1限制的T细胞作为“自身效应细胞”发挥作用，在与表达CD1的抗原呈递细胞相互作用时会迅速被刺激以执行辅助和效应功能。受CD1限制的T细胞亚群之间的功能差异，以及这些细胞影响树突状细胞的炎症和致耐受性效应并激活自然杀伤细胞及其他淋巴细胞的途径，为了解受CD1限制的T细胞如何调节抗菌反应、抗肿瘤免疫以及耐受性与自身免疫之间的平衡提供了线索。
