Olsson R A, Davis C J, Khouri E M, Patterson R E
Circ Res. 1976 Jul;39(1):93-8. doi: 10.1161/01.res.39.1.93.
Adenosine and theophylline were linked covalently to oxidized stachyose to produce compounds too large to penetrate cell membranes. These compounds were used in two conscious and six open-chest anesthetized dogs to test the hypothesis that there is an adenosine receptor on the surface of the coronary myocyte. Intracoronary infusions of the adenosine derivative produced dose-dependent coronary vasodilation which was antagonized by theophylline; two types of theophylline derivative antagonized the coronary vasodilatory action of adenosine. Although these results show that both adenosine and theophylline exert their coronary effects at the surface of the smooth muscle cells, this evidence does not establish that they are competing for a common receptor.
将腺苷和茶碱共价连接到氧化的水苏糖上，生成太大而无法穿透细胞膜的化合物。这些化合物被用于两只清醒和六只开胸麻醉犬，以检验冠状动脉心肌细胞表面存在腺苷受体这一假说。冠状动脉内注入腺苷衍生物可产生剂量依赖性冠状动脉扩张，该作用可被茶碱拮抗；两种茶碱衍生物可拮抗腺苷的冠状动脉扩张作用。尽管这些结果表明腺苷和茶碱均在平滑肌细胞表面发挥其冠状动脉效应，但这一证据并不能确定它们是在竞争共同的受体。
