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1
Adenosine inhibition of gamma-aminobutyric acid release from slices of rat cerebral cortex.腺苷对大鼠大脑皮层切片中γ-氨基丁酸释放的抑制作用。
Br J Pharmacol. 1980 May;69(1):107-12. doi: 10.1111/j.1476-5381.1980.tb10888.x.
2
Effects of adenosine and related compounds on an inhibitory process in rat cerebral cortex.腺苷及相关化合物对大鼠大脑皮层抑制过程的影响。
Exp Neurol. 1980 Dec;70(3):556-66. doi: 10.1016/0014-4886(80)90182-x.
3
Baclofen and phaclofen modulate GABA release from slices of rat cerebral cortex and spinal cord but not from retina.巴氯芬和苯环戊芬可调节大鼠大脑皮层和脊髓切片中γ-氨基丁酸（GABA）的释放，但对视网膜切片中的GABA释放无调节作用。
Br J Pharmacol. 1989 Sep;98(1):105-12. doi: 10.1111/j.1476-5381.1989.tb16869.x.
4
Modulation of gamma-aminobutyric acid release in cerebral cortex by fluoride, phorbol ester, and phosphodiesterase inhibitors: differential sensitivity of acetylcholine release to fluoride and K+ channel blockers.氟化物、佛波酯和磷酸二酯酶抑制剂对大脑皮层中γ-氨基丁酸释放的调节：乙酰胆碱释放对氟化物和钾通道阻滞剂的不同敏感性。
J Neurochem. 1990 Apr;54(4):1130-5. doi: 10.1111/j.1471-4159.1990.tb01939.x.
5
An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus.腺苷激动剂可抑制大鼠齿状回切片中谷氨酸的释放，但不影响γ-氨基丁酸（GABA）的释放；而环磷酸腺苷类似物则可增强谷氨酸的释放，同样不影响GABA的释放。
Neurosci Lett. 1983 Dec 23;43(1):49-54. doi: 10.1016/0304-3940(83)90127-1.
6
Adenosine receptor agonists inhibit the release of gamma-aminobutyric acid (GABA) from the ischemic rat cerebral cortex.腺苷受体激动剂可抑制缺血大鼠大脑皮质中γ-氨基丁酸（GABA）的释放。
Brain Res. 1992 Jun 5;582(1):22-6. doi: 10.1016/0006-8993(92)90312-w.
7
Development of tolerance to the effects of vigabatrin (gamma-vinyl-GABA) on GABA release from rat cerebral cortex, spinal cord and retina.对氨己烯酸（γ-乙烯基-GABA）对大鼠大脑皮层、脊髓和视网膜GABA释放影响的耐受性的发展。
Br J Pharmacol. 1990 Jun;100(2):324-8. doi: 10.1111/j.1476-5381.1990.tb15803.x.
8
Endogenous GABA release from slices of rat cerebral cortex and hippocampus in vitro.体外大鼠大脑皮层和海马体切片中内源性γ-氨基丁酸的释放
Brain Res. 1982 Mar 11;235(2):265-70. doi: 10.1016/0006-8993(82)91006-x.
9
Methylxanthines modulate adenosine release from slices of cerebral cortex.甲基黄嘌呤可调节大脑皮质切片中腺苷的释放。
Brain Res. 1981 Mar 2;207(2):421-31. doi: 10.1016/0006-8993(81)90374-7.
10
Influence of aminooxyacetic acid on the potassium-evoked release of [3H]gamma-aminobutyric acid from slices of rat cerebral cortex.氨氧基乙酸对大鼠大脑皮层切片中钾离子诱发的[3H]γ-氨基丁酸释放的影响。
Neurochem Res. 1984 Aug;9(8):1101-8. doi: 10.1007/BF00964805.

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The neurophysiological effects of single-dose theophylline in patients with chronic stroke: A double-blind, placebo-controlled, randomized cross-over study.单剂量茶碱对慢性中风患者的神经生理影响：一项双盲、安慰剂对照、随机交叉研究。
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Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.从星形胶质细胞释放的嘌呤抑制脊髓腹角的兴奋性突触传递。
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Neurochem Res. 2010 Dec;35(12):1948-56. doi: 10.1007/s11064-010-0265-5. Epub 2010 Sep 26.
4
GABA release under normal and ischemic conditions.正常和缺血条件下的γ-氨基丁酸释放
Neurochem Res. 2008 May;33(5):962-9. doi: 10.1007/s11064-007-9499-2. Epub 2007 Oct 17.
5
GABA release modified by adenosine receptors in mouse hippocampal slices under normal and ischemic conditions.在正常和缺血条件下，小鼠海马切片中腺苷受体对γ-氨基丁酸释放的调节作用。
Neurochem Res. 2005 Apr;30(4):467-73. doi: 10.1007/s11064-005-2682-4.
6
Effects of aluminum chloride on the kinetics of rat cortex synaptosomal ATP diphosphohydrolase (EC 3.6.1.5).氯化铝对大鼠皮层突触体ATP二磷酸水解酶（EC 3.6.1.5）动力学的影响。
Biol Trace Elem Res. 1995 Dec;50(3):209-19. doi: 10.1007/BF02785411.
7
The influence of caffeine on human EEG under resting conditions and during mental loads.咖啡因在静息状态和精神负荷状态下对人类脑电图的影响。
Clin Investig. 1993 Mar;71(3):197-207. doi: 10.1007/BF00180102.
8
Bicuculline-resistant paired-pulse inhibition in the rat hippocampal slice.大鼠海马切片中对荷包牡丹碱耐药的双脉冲抑制
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9
The effect of calcium removal on the suppression by adenosine of epileptiform activity in the hippocampus: demonstration of desensitization.去除钙对腺苷抑制海马癫痫样活动的影响：脱敏作用的证明。
Br J Pharmacol. 1994 May;112(1):316-22. doi: 10.1111/j.1476-5381.1994.tb13071.x.
10
Release and actions of adenosine in the central nervous system.腺苷在中枢神经系统中的释放及作用。
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本文引用的文献

1
The effect of electrical stimulation and high potassium concentrations on the efflux of (3H) gamma-aminobutyric acid from brain slices.电刺激和高钾浓度对脑片（3H）γ-氨基丁酸流出的影响。
J Neurochem. 1969 Aug;16(8):1235-44. doi: 10.1111/j.1471-4159.1969.tb05971.x.
2
Cortical inhibition and gamma-aminobutyric acid.皮质抑制与γ-氨基丁酸
Exp Brain Res. 1969;9(2):137-54. doi: 10.1007/BF00238327.
3
Purinergic nerves.嘌呤能神经
Pharmacol Rev. 1972 Sep;24(3):509-81.
4
Adenosine-mediated elevation of cyclic 3':5'-adenosine monophosphate concentrations in cultured mouse neuroblastoma cells.腺苷介导培养的小鼠神经母细胞瘤细胞中3':5'-环磷酸腺苷浓度的升高。
Proc Natl Acad Sci U S A. 1973 Nov;70(11):3099-102. doi: 10.1073/pnas.70.11.3099.
5
The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.腺苷及腺嘌呤核苷酸对豚鼠大脑皮层切片中3',5'-环磷酸腺苷含量的影响。
Mol Pharmacol. 1970 Jan;6(1):13-23.
6
The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat.腺苷对大鼠膈神经递质释放的影响。
J Physiol. 1972 Aug;224(3):629-45. doi: 10.1113/jphysiol.1972.sp009916.
7
Proceedings: On the release of accumulated (3-H)-gamma-aminobutyric acid (GABA) from isolated rat superior cervical ganglia.论文集：关于从离体大鼠颈上神经节释放累积的（3-H）-γ-氨基丁酸（GABA）
Br J Pharmacol. 1974 Nov;52(3):436P-437P.
8
Regulatory significance of the release and action of adenine derivatives in cerebral systems.腺嘌呤衍生物在脑系统中的释放及作用的调节意义
Biochem Soc Symp. 1972(36):69-85.
9
Evidence for an adenosine receptor on the surface of dog coronary myocytes.犬冠状动脉心肌细胞表面存在腺苷受体的证据。
Circ Res. 1976 Jul;39(1):93-8. doi: 10.1161/01.res.39.1.93.
10
Inhibition of acetylcholine release from cholinergic nerves by adenosine, adenine nucleotides and morphine: antagonism by theophylline.腺苷、腺嘌呤核苷酸和吗啡对胆碱能神经乙酰胆碱释放的抑制作用：茶碱的拮抗作用。
J Pharmacol Exp Ther. 1976 May;197(2):379-90.

腺苷对大鼠大脑皮层切片中γ-氨基丁酸释放的抑制作用。

Adenosine inhibition of gamma-aminobutyric acid release from slices of rat cerebral cortex.

作者信息

Hollins C, Stone T W

出版信息

Br J Pharmacol. 1980 May;69(1):107-12. doi: 10.1111/j.1476-5381.1980.tb10888.x.

DOI:10.1111/j.1476-5381.1980.tb10888.x
PMID:7378648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044167/
Abstract

1 The effect of purine compounds on the potassium-evoked release of 14C-labelled gamma-aminobutyric acid (GABA) has been studied in 400 micrometers slices of rat cerebral cortex in vitro. 2 Adenosine and adenosine 5' monophosphate (AMP) inhibited the release of GABA at 10(-5) to 10(-3) M. Adenosine triphosphate (ATP) produced a significant inhibition of release only at 10(-3) M. 3 Theophylline 10(-4) or 10(-3) M reduced the inhibitory effect of adenosine, but did not change basal release of GABA. 4 Dipyridamole 10(-5) M itself reduced evoked GABA release, but did not prevent the inhibitory effect of adenosine, implying that adenosine was acting at an extracellularly directed receptor. 5 Calcium removal or antagonism by verapamil reduced the evoked release of GABA, but adenosine did not produce any further reduction of the calcium-independent release. This may indicate that the inhibitory effect of adenosine on GABA release results from interference with calcium influx or availability within the terminals.

摘要

  1. 嘌呤化合物对体外培养的400微米厚大鼠大脑皮质切片中钾离子诱发的14C标记γ-氨基丁酸（GABA）释放的影响已被研究。

  2. 腺苷和5'-磷酸腺苷（AMP）在10^(-5)至10^(-3)M浓度下抑制GABA的释放。三磷酸腺苷（ATP）仅在10^(-3)M时对释放产生显著抑制作用。

  3. 10^(-4)或10^(-3)M的茶碱可降低腺苷的抑制作用，但不改变GABA的基础释放量。

  4. 10^(-5)M的双嘧达莫本身可降低诱发的GABA释放，但不能阻止腺苷的抑制作用，这表明腺苷作用于细胞外定向受体。

  5. 去除钙离子或用维拉帕米拮抗可降低诱发的GABA释放，但腺苷不会使非钙依赖性释放进一步降低。这可能表明腺苷对GABA释放的抑制作用是由于干扰了神经末梢内的钙离子内流或可利用性。