Zueva N A, Sologub N V, Efimov A S
Lik Sprava. 2003(2):35-9.
In the review, data are presented on glymepiride (amaril), a 3-d generation sulphanylamide. The drug interacts with receptors to sulphonylurea--SUR X, that are found only in B-cells of the pancreas, which fact has been shown to be associated with a higher secretion of insulin, an increased sensitivity of peripheral tissues to this hormone and with insulin-like extrapancreatic effects as well. Amaril does not affect SUR of the myocardium, myocytes of cerebral vessels and nervous cells. The use of the above drug combined with metformin, insulin, repaglynide, and nateglynide has been shown to be an optimum treatment option, however in the latter case, hypoglycemic states may come to be seen more frequently along with a rapid exhaustion of B-cells. In view of the fact that in many instances, type 2 diabetes mellitus runs its course concurrently with other illness, it is necessary that interaction of amaril with other drugs be taken into account.
在这篇综述中，给出了关于第三代磺酰胺类药物格列美脲（亚莫利）的数据。该药物与仅在胰腺β细胞中发现的磺酰脲受体——SUR X相互作用，这一事实已被证明与胰岛素分泌增加、外周组织对该激素的敏感性增强以及胰岛素样的胰腺外效应有关。亚莫利不影响心肌、脑血管肌细胞和神经细胞的SUR。已证明将上述药物与二甲双胍、胰岛素、瑞格列奈和那格列奈联合使用是最佳治疗选择，然而在后一种情况下，低血糖状态可能更频繁出现，同时β细胞会迅速耗竭。鉴于在许多情况下，2型糖尿病与其他疾病同时发生，有必要考虑亚莫利与其他药物的相互作用。
