Johnson K, Cazee C, Gutch C, Ogden D
Clin Nephrol. 1976 Jun;5(6):266-8.
A stable candy with 5.0 g sodium polystyrene sulfonate resin per piece was developed. In vitro testing indicated decrease in potassium concentration of 1.0 mEq per gram of resin. Six chronic dialysis patients with predialysis serum potassium of 5.2 mEq per liter or greater participated in a two week blind trial. No change in diet or dialysis routine was made during the study. Analysis of serum potassium by paired "t" test showed mean potassium decrease of 0.7 mEq per liter during treatment (P less than 0.001). Patient compliance and acceptance was excellent during the trial. Use in the treatment of chronic hyperkalemia may be worthwhile in the care of long-term dialysis patients.
研制出了一种每片含5.0克聚苯乙烯磺酸钠树脂的稳定糖果。体外测试表明，每克树脂可使钾浓度降低1.0毫当量。六名透析前血清钾浓度为每升5.2毫当量或更高的慢性透析患者参与了一项为期两周的盲法试验。研究期间，患者的饮食或透析常规未作改变。通过配对“t”检验分析血清钾发现，治疗期间平均钾浓度降低了0.7毫当量/升（P<0.001）。试验期间患者的依从性和接受度都很好。在长期透析患者的护理中，使用该糖果治疗慢性高钾血症可能是值得的。
