[白芷精油对疼痛模型大鼠β-内啡肽、促肾上腺皮质激素、一氧化氮及阿片促黑激素皮质素原的影响]
[Effect of essential oil of Radix Angelicae Dahuricae on beta-endorphin, ACTH, NO and proopiomelanocortin of pain model rats].
作者信息
Nie Hong, Shen Ying-jun
机构信息
Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2002 Sep;27(9):690-3.
OBJECTIVE
To investigate the effect of essential oil of Radix Aangelicae Dahuricae (EOAD) on beta-endorphin Adrenocorticotropic hormone(ACTH), Nitric oxide (NO) and Proopiomelanocortin (POMC) of pain model rats induced by formaldehyde.
METHOD
beta-endorphin and ACTH were detected with radio-immunity, the amount of masculine cell expression of Proopiomelanocortin mRNA in hypothalamus, and brainstem of pain model was detected with in situ hybridization and NO with chemical method.
RESULT
EOAD could increase beta-endorphin, NO and the amount of masculine cell expression of Proopiomelanocortin mRNA significantly in hypothalamus and brainstem of rats.
CONCLUSION
EOAD which may be central analgesic, is associated with endogenous opiate-like substance such as POMC and beta-endorphin.
目的
探讨白芷挥发油（EOAD）对甲醛致痛模型大鼠β-内啡肽、促肾上腺皮质激素（ACTH）、一氧化氮（NO）及阿片促黑皮质素原（POMC）的影响。
方法
采用放射免疫法检测β-内啡肽和ACTH，原位杂交法检测痛觉模型大鼠下丘脑和脑干中POMC mRNA阳性细胞表达量，化学法检测NO。
结果
EOAD可显著增加大鼠下丘脑和脑干中β-内啡肽、NO含量及POMC mRNA阳性细胞表达量。
结论
EOAD可能具有中枢镇痛作用，与POMC、β-内啡肽等内源性阿片样物质有关。
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