目前关于蛋白质折叠机制的观点。
The present view of the mechanism of protein folding.
作者信息
Daggett Valerie, Fersht Alan
机构信息
Department of Medicinal Chemistry, Box 357610, University of Washington, Seattle, Washington 98195-7610, USA.
出版信息
Nat Rev Mol Cell Biol. 2003 Jun;4(6):497-502. doi: 10.1038/nrm1126.
DOI:10.1038/nrm1126
PMID:12778129
Abstract
We can track the positions and movements of all the atoms in small proteins as they fold and unfold by combining experimental studies with atomic-resolution molecular dynamics simulations. General principles as to how such complex architectures form so rapidly are now emerging from in-depth studies of a few proteins.
摘要
通过将实验研究与原子分辨率分子动力学模拟相结合，我们可以追踪小蛋白质折叠和解折叠过程中所有原子的位置和运动。关于如此复杂的结构如何快速形成的一般原理，现在正从对少数蛋白质的深入研究中逐渐显现出来。
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