使用超临界二氧化碳通过半连续流动过程对酮进行生物催化还原。
Biocatalytic reduction of ketones by a semi-continuous flow process using supercritical carbon dioxide.
作者信息
Matsuda Tomoko, Watanabe Kazunori, Kamitanaka Takashi, Harada Tadao, Nakamura Kaoru
机构信息
Department of Materials Chemistry, Faculty of Science and Technology, Ryukoku University, Otsu, Shiga 520-2194, Japan.
出版信息
Chem Commun (Camb). 2003 May 21(10):1198-9. doi: 10.1039/b301452e.
DOI:10.1039/b301452e
PMID:12778733
Abstract
The immobilized resting-cell of Geotrichum candidum was used as a catalyst for the reduction of a ketone in a semi-continuous flow process using supercritical carbon dioxide for the first time; it was also applied for the asymmetric reduction of a ketone and resulted in excellent enantioselectivity (ee > 99%) and a higher space-time yield than that of the corresponding batch process.
摘要
首次使用米根霉的固定化静息细胞作为催化剂，在半连续流动过程中利用超临界二氧化碳还原酮；它还被用于酮的不对称还原，得到了优异的对映选择性（对映体过量>99%），并且时空产率高于相应的间歇过程。
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