Liu Haoliang, Feng Juan, Zhang Jianyong, Miller Philip W, Chen Liuping, Su Cheng-Yong
MOE Laboratory of Bioinorganic and Synthetic Chemistry , MOE Key Laboratory of Polymeric Composite and Functional Materials , Lehn Institute of Functional Materials , School of Chemistry and Chemical Engineering , Sun Yat-Sen University , Guangzhou , 510275 , China . Email:
Department of Chemistry , Imperial College London , London , SW7 2AZ , UK . Email:
Chem Sci. 2015 Apr 16;6(4):2292-2296. doi: 10.1039/c5sc00314h. Epub 2015 Feb 18.
A novel dynamic covalent gel strategy is reported to immobilize an asymmetric catalyst within the channels of a microfluidic flow reactor. A layer of a catalytically active Mn-salen dynamic covalent imine gel matrix was coated onto a functionalized capillary. Mn-salen active moiety was incorporated into dynamic covalent imine gel matrix the reaction of a chiral Mn-salen dialdehyde unit with a tetraamine linker. The catalytic activity of the capillary reactor has been demonstrated in enantioselective kinetic resolution of secondary alcohols.
据报道，一种新型的动态共价凝胶策略可将不对称催化剂固定在微流控流动反应器的通道内。将一层具有催化活性的锰-萨伦动态共价亚胺凝胶基质涂覆在功能化毛细管上。通过手性锰-萨伦二醛单元与四胺连接体的反应，将锰-萨伦活性部分引入到动态共价亚胺凝胶基质中。该毛细管反应器的催化活性已在仲醇的对映选择性动力学拆分中得到证实。
