Patten B M, Mallette L E
Dis Nerv Syst. 1976 Jun;37(6):318-21.
In a retrospective study of the charts of 39 patients who had motor neuron disease we found that over 50 percent of patients had radiographic abnormalities of bone and over 20 percent had serum calcium concentrations out of the range observed in normal controls. Statistical analysis indicated that, in respect to serum calcium levels, patients who have motor neuron disease are a separate population. These findings, which might reflect a disturbance in bone or calcium metabolism in patients with motor neuron disease, are of interest in view of the known ability of divalent ions other than calcium, such as lead and mercury, to simulate motor neuron disease, and the discovery that patients with proven primary and secondary hyperparathyroidism may have features of amyotrophic lateral sclerosis.
在一项对39例运动神经元病患者病历的回顾性研究中，我们发现超过50%的患者存在骨骼的影像学异常，超过20%的患者血清钙浓度超出正常对照组的观测范围。统计分析表明，就血清钙水平而言，运动神经元病患者是一个独立的群体。这些发现可能反映了运动神经元病患者骨或钙代谢的紊乱，鉴于除钙以外的二价离子（如铅和汞）有模拟运动神经元病的能力，以及已证实的原发性和继发性甲状旁腺功能亢进患者可能有肌萎缩侧索硬化的特征，这些发现很有意思。
