Abernethy J D
Drugs. 1976;11 SUPPL 1:86-90. doi: 10.2165/00003495-197600111-00022.
Of 1,593 subjects admitted to the Australian National Blood Pressure Study 1 to 2 years ago, a substantial number (391 or 24.5%) ceased attending, in 85% of cases voluntarily. Withdrawal rates were very high in the first 4 months, settling to 5% per annum by the second year. Extrapolation to clinical practice is hazardous but contibutory factors elicited by questionnaire suggest certain management strategies: maximisation of efforts to enlist subject co-operation at the onset of treatment; management of treatment by family doctor or health centre with appointments flexible in time and infrequent in number; minimisation of doctors' ambivalence about treatment effectiveness and the withholding of information from the subject. It is inevitable that a proportion of subjects will reject long-term drug treatment. This adds further weight to the need for research on alternatives such as low salt diets.
在1至2年前参加澳大利亚国家血压研究的1593名受试者中，相当一部分人（391名，占24.5%）不再参与研究，其中85%的情况是自愿退出。在前4个月退出率非常高，到第二年稳定在每年5%。将这些情况外推到临床实践存在风险，但通过问卷调查得出的促成因素提示了某些管理策略：在治疗开始时最大程度争取受试者的合作；由家庭医生或健康中心进行治疗管理，预约时间灵活且次数少；尽量减少医生对治疗效果的矛盾态度以及向受试者隐瞒信息的情况。不可避免的是，一部分受试者会拒绝长期药物治疗。这进一步凸显了对低盐饮食等替代方案进行研究的必要性。
