Graham R M
Clin Ther. 1983;5(3):224-33.
The indications for treatment of hypertension, the goals of therapy, and the effects of long-term treatment are considered. The importance of individualized therapy (eg, for systolic hypertension, for borderline hypertension, and for hypertension in the elderly) and the problems of noncompliance, tolerance, and withdrawal are discussed. Beneficial and adverse effects of long-term treatment with beta-blockers, captopril, clonidine, diuretics, guanethidine, hydralazine, methyldopa, minoxidil, prazosin, and reserpine are outlined.
文中考虑了高血压的治疗指征、治疗目标以及长期治疗的效果。讨论了个体化治疗的重要性（如对收缩期高血压、临界高血压和老年高血压患者）以及不依从性、耐受性和撤药问题。概述了β受体阻滞剂、卡托普利、可乐定、利尿剂、胍乙啶、肼屈嗪、甲基多巴、米诺地尔、哌唑嗪和利血平长期治疗的有益和不良影响。
