浆细胞异常增生症中血浆sMUC-1水平的患病率及预后意义。

Prevalence and prognostic significance of sMUC-1 levels in plasma cell dyscrasias.

作者信息

Luminari Stefano, Goldaniga Maria, Ceccherelli Fulvia, Guffanti Andrea, Bombardieri Emilio, Marcheselli Raffaella, Cro Lilla, Colombi Mariangela, Federico Massimo, Baldini Luca

机构信息

Dipartimento di Oncologia ed Ematologia, Università di Modena e Reggio Emilia, Milan, Italy.

出版信息

Br J Haematol. 2003 Jun;121(5):772-4. doi: 10.1046/j.1365-2141.2003.04353.x.

DOI:10.1046/j.1365-2141.2003.04353.x

PMID:12780792

Abstract

High serum Mucin-1 (sMUC-1) levels have been shown in patients with adenocarcinoma and multiple myeloma (MM). We evaluated sMUC-1 levels in 76 patients with MM, 6 with plasma cells leukaemia (PCL) and 89 with monoclonal gammopathy of undetermined significance, to establish prevalence data and verify its possible prognostic role. Of the 171 patients, 27 [16%; 95% confidence interval (CI): 10-21%] had high sMUC-1 levels compared with healthy subjects (1.5%; 95% CI: 0-4%). Elevated sMUC-1 levels in MM and PCL patients correlated with anaemia and elevated serum lactate dehydrogenase levels; these patients showed a shorter survival than those with normal sMUC-1 levels (median overall survival: 25 vs. 49 months, P = 0.003).

摘要

腺癌和多发性骨髓瘤（MM）患者血清粘蛋白-1（sMUC-1）水平较高。我们评估了76例MM患者、6例浆细胞白血病（PCL）患者和89例意义未明的单克隆丙种球蛋白病患者的sMUC-1水平，以建立患病率数据并验证其可能的预后作用。在这171例患者中，与健康受试者（1.5%；95%置信区间：0-4%）相比，27例[16%；95%置信区间（CI）：10-21%]sMUC-1水平较高。MM和PCL患者sMUC-1水平升高与贫血和血清乳酸脱氢酶水平升高相关；这些患者的生存期比sMUC-1水平正常的患者短（中位总生存期：25个月对49个月，P=0.003）。