Carmon E, Keidar A, Ravid A, Goldman G, Rabau M
Proctology Unit, Department of Surgery B, Tel-Aviv Sourasky Medical Centre, Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizmann Street, Tel-Aviv 64239, Israel.
Colorectal Dis. 2003 May;5(3):228-32. doi: 10.1046/j.1463-1318.2003.00445.x.
The aim of this study was to evaluate functional outcome and quality of life (QOL) in patients undergoing proctocolectomy ileal pouch anal anastomosis (IPAA), to assess the correlation between functional outcome and QOL, and to identify factors influencing functional outcome and QOL in these patients.
IPAA is now considered the procedure of choice for ulcerative colitis. Functional outcome and QOL are important factors in evaluating operative outcome.
All patients with UC who had undergone IPAA at our institute during the period 1990-2001 were included. QOL and functional outcome were evaluated by mailed questionnaires. QOL was scored using the Short Form 36 (SF-36). Global Assessment of Function Scale was used to evaluate functional outcome.
Data were obtained in 77 of 99 patients (78%), with the median age of 38 years. Median follow up time was 4.25 years. The QOL in patients after pelvic pouch procedure was excellent, with scores equal to published norms for the Israeli general population in most scales. Functional outcome and QOL scores correlated strongly (r > 0.5; P < 0.0001) in all dimensions. Older age was associated with lower scores in both functional outcome and QOL scales (P < 0.0001).
This study demonstrates a strong association between functional outcome and QOL in patients after IPAA. These patients, however, have a QOL that is comparable with the general population. Age at time of surgery strongly influences both functional outcome and QOL. This finding has to be taken into consideration in pre-operative counseling.
本研究旨在评估接受全结直肠切除回肠储袋肛管吻合术（IPAA）患者的功能结局和生活质量（QOL），评估功能结局与生活质量之间的相关性，并确定影响这些患者功能结局和生活质量的因素。
IPAA目前被认为是溃疡性结肠炎的首选手术方式。功能结局和生活质量是评估手术效果的重要因素。
纳入1990年至2001年期间在我院接受IPAA的所有溃疡性结肠炎患者。通过邮寄问卷评估生活质量和功能结局。使用简短健康调查问卷（SF-36）对生活质量进行评分。采用功能综合评定量表评估功能结局。
99例患者中的77例（78%）提供了数据，中位年龄为38岁。中位随访时间为4.25年。盆腔储袋手术后患者的生活质量良好，在大多数量表上的得分与以色列普通人群公布的标准相当。功能结局和生活质量得分在所有维度上均呈强相关（r>0.5；P<0.0001）。年龄较大与功能结局和生活质量量表得分较低相关（P<0.0001）。
本研究表明IPAA术后患者的功能结局与生活质量之间存在密切关联。然而，这些患者的生活质量与普通人群相当。手术时的年龄强烈影响功能结局和生活质量。这一发现必须在术前咨询中予以考虑。
