Perna Giampaolo, Romano Pietra, Caldirola Daniela, Cucchi Michele, Bellodi Laura
Anxiety Disorders Clinical and Research Unit, Department of Neuropsychiatric Sciences, Istituto Scientifico HS Raffaele, 29 via Prinetti, 20127 Milan, Italy.
J Psychosom Res. 2003 Jun;54(6):573-7. doi: 10.1016/s0022-3999(02)00468-3.
The present study examines the possible relationships between anxiety sensitivity (AS) and reactivity to the 35% carbon dioxide (CO(2)) challenge in panic disorder (PD).
One-hundred eight patients with PD underwent the 35% CO(2) challenge and completed the Anxiety Sensitivity Index (ASI). Multiple regression analyses were applied to evaluate the role of AS as a predictor of CO(2)-induced anxiety.
Fifty-six patients with PD showed high AS scores, whereas 48 showed medium scores and 4 low scores. ASI scores significantly predicted symptomatological reaction to CO(2) but not subjective induced anxiety.
These findings suggest that the fear of anxiety-related bodily sensations was related to the symptomatological reactivity to CO(2) but did not seem to play a crucial role in the modulation of the subjective anxiogenic/panicogenic response to hypercapnia in patients with PD.
本研究探讨惊恐障碍（PD）患者的焦虑敏感性（AS）与对35%二氧化碳（CO₂）激发试验的反应之间可能存在的关系。
108例PD患者接受了35% CO₂激发试验，并完成了焦虑敏感性指数（ASI）测试。应用多元回归分析来评估AS作为CO₂诱发焦虑预测指标的作用。
56例PD患者AS得分高，48例得分中等，4例得分低。ASI得分显著预测了对CO₂的症状反应，但不能预测主观诱发的焦虑。
这些发现表明，对与焦虑相关的身体感觉的恐惧与对CO₂的症状反应性有关，但在PD患者对高碳酸血症的主观致焦虑/致惊恐反应的调节中似乎不起关键作用。
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