在惊恐障碍、社交恐惧症和健康对照组中，重复吸入 20% CO₂ 富集空气时的呼吸、自主和体验反应。
Respiratory, autonomic, and experiential responses to repeated inhalations of 20% CO₂ enriched air in panic disorder, social phobia, and healthy controls.
机构信息
Department of Clinical Psychology and Psychotherapy, Institute for Psychology, University of Freiburg, Germany.
出版信息
Biol Psychol. 2010 Apr;84(1):104-11. doi: 10.1016/j.biopsycho.2010.01.002. Epub 2010 Jan 12.
Inhalation of carbon dioxide (CO₂) enriched air triggers anxiety in panic disorder (PD) patients, which is often interpreted as a sign of biological vulnerability. However, most studies have not measured respiration in these tasks. We compared patients with PD (n=20) and social phobia (SP, n=19) to healthy controls (n=18) during eight inhalations of 20% CO₂, preceded and followed by two inhalations of room air, while continuously measuring subjective anxiety and dyspnea as well as autonomic and respiratory variables. PD patients showed increased reactivity and delayed recovery during CO₂ inhalations for most measures. Unlike both other groups, the PD group's tidal volume responses did not habituate across CO₂ inhalations. However, PD patients did not differ from SP patients on most other measures, supporting a continuum model of CO₂ sensitivity across anxiety disorders. Both patient groups showed continued reactivity during the last air inhalations, which is unlikely to be due to a biological sensitivity.
吸入二氧化碳（CO₂）富集空气会引发恐慌症（PD）患者的焦虑，这通常被解释为生物脆弱性的标志。然而，大多数研究在这些任务中并未测量呼吸。我们比较了 20 名恐慌症（PD）患者、19 名社交恐惧症（SP）患者和 18 名健康对照组在吸入 20% CO₂的 8 次过程中的表现，在此期间，连续测量主观焦虑和呼吸困难，以及自主和呼吸变量。PD 患者在 CO₂吸入期间的大多数指标上表现出反应性增加和恢复延迟。与其他两组不同的是，PD 组的潮气量反应在 CO₂吸入过程中没有习惯化。然而，PD 患者在大多数其他指标上与 SP 患者没有差异，支持焦虑障碍 CO₂敏感性的连续模型。两组患者在最后一次空气吸入时均表现出持续的反应性，这不太可能是由于生物敏感性所致。
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