Bhattacharyya Ashim K, Strong Jack P
Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Exp Mol Pathol. 2003 Jun;74(3):291-7. doi: 10.1016/s0014-4800(03)00018-2.
In two long-term studies of dietary-cholesterol-induced atherosclerosis lesions in rhesus monkeys, we determined the fatty acid composition of cholesteryl esters in the arterial intima-media preparations. In the first study (2-year study) monkeys were fed an atherogenic diet for 2 years; in the second study, (5-year study), monkeys were fed the atherogenic diet for about 5.4 years. Dietary cholesterol was removed from regressed animals and the regression periods in the 2-year study were 30 and 52 weeks and in the 5-year study were 20, 30, 52, 101, and 191 weeks. In both studies in thoracic and abdominal aortic segments, the percent removal of 18:2 cholesteryl ester (CE) was small, whereas percent removal of 18:1 CE and other CEs was much higher. We postulate that 18:2 CE is not hydrolyzed to the extent comparable to 18:1 and other CEs in lesions. Perhaps 18:2 CE is not a preferred substrate for arterial neutral cholesterol ester hydrolase.
在两项关于恒河猴饮食胆固醇诱导动脉粥样硬化病变的长期研究中，我们测定了动脉内膜 - 中膜制剂中胆固醇酯的脂肪酸组成。在第一项研究（2年研究）中，猴子喂食致动脉粥样化饮食2年；在第二项研究（5年研究）中，猴子喂食致动脉粥样化饮食约5.4年。从病情消退的动物中去除饮食中的胆固醇，在2年研究中的消退期为30周和52周，在5年研究中的消退期为20周、30周、52周、101周和191周。在两项研究的胸主动脉和腹主动脉段中，18:2胆固醇酯（CE）的去除百分比很小，而18:1 CE和其他CE的去除百分比要高得多。我们推测，在病变中18:2 CE的水解程度不如18:1和其他CE。也许18:2 CE不是动脉中性胆固醇酯水解酶的首选底物。
