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用降脂剂（2-（对氯苯氧基）异丁酸乙酯）治疗的高胆固醇喂养兔中胆固醇酯的脂肪酸组成

Fatty acid composition of cholesteryl esters in cholesterol-fed rabbits treated with lipid-lowering agent (ethyl 2-(p-chlorophenoxy) isobutyrate).

作者信息

Sato M, Takano T

出版信息

Jpn J Pharmacol. 1979 Apr;29(2):261-9. doi: 10.1254/jjp.29.261.

DOI:10.1254/jjp.29.261
PMID:537249
Abstract

Regression mechanism of Ethyl 2-(p-chlorophenoxy) isobutyrate (CPIB) in the arterial wall was studied for elucidation in terms of fatty acid-compositional change in cholesterol-fed rabbits. The following evidence was obtained: (1) The amount of cholesterol and cholesteryl ester in the atheromatous aorta were reduced after CPIB treatment. (2) CPIB resulted in a significant increase in the ratio of linoleate to oleate in both the arterial wall and serum after withdrawal of the cholesterol diet. It is suggested that there is a preferential hydrolysis of linoleate-rich cholesteryl ester in both the arterial wall and the serum.

摘要

为了从喂食胆固醇的兔子脂肪酸组成变化方面进行阐明，研究了2-（对氯苯氧基）异丁酸乙酯（CPIB）在动脉壁中的消退机制。获得了以下证据：（1）CPIB处理后，动脉粥样硬化主动脉中的胆固醇和胆固醇酯含量降低。（2）停止胆固醇饮食后，CPIB导致动脉壁和血清中亚油酸与油酸的比例显著增加。提示在动脉壁和血清中富含亚油酸的胆固醇酯存在优先水解。

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1
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