Shigenaga Y, Inoki R
Eur J Pharmacol. 1976 Apr;36(2):347-53. doi: 10.1016/0014-2999(76)90088-1.
The effects of morphine and barbiturate on the evoked potentials recorded from the primary and secondary somatic sensory areas of rats were investigated. The electric stimulation of contra- and ipsilateral tooth pulp (CTP and ITP) was used. The afferent impulse from dental pulp projected to the sensory face areas I and II (SI and SII). Morphine in doses of 2.5-10 mg/kg definitely inhibited SI and SII potentials evoked by CTP stimulation. Morphine also inhibited SII potentials evoked by ITP stimulation, while it rather enhanced SI potentials evoked by ITP stimulation. Pentobarbital sodium in doses of 4-16 mg/kg tended to inhibit SI potentials, but showed no effect or rather an enhancement on SII potentials evoked by CTP stimulation. Pentobarbital sodium enhanced SI and SII potentials evoked by ITP stimulation. In a large dose of 32 mg/kg, pentobarbital sodium inhibited SI and SII potentials evoked by ITP and CTP stimulations. The results suggest that SII is more closely related to the analgesia due to morphine than is SI.
研究了吗啡和巴比妥类药物对大鼠初级和次级躯体感觉区记录的诱发电位的影响。采用对侧和同侧牙髓电刺激（CTP和ITP）。来自牙髓的传入冲动投射到感觉面部区域I和II（SI和SII）。2.5-10mg/kg剂量的吗啡明显抑制CTP刺激诱发的SI和SII电位。吗啡也抑制ITP刺激诱发的SII电位，而对ITP刺激诱发的SI电位有增强作用。4-16mg/kg剂量的戊巴比妥钠倾向于抑制SI电位，但对CTP刺激诱发的SII电位无影响或有增强作用。戊巴比妥钠增强ITP刺激诱发的SI和SII电位。在32mg/kg的大剂量下，戊巴比妥钠抑制ITP和CTP刺激诱发的SI和SII电位。结果表明，与SI相比，SII与吗啡镇痛的关系更密切。
