吗啡对大鼠丘脑神经元伤害性反应的选择性作用。
Selective effects of morphine on the nociceptive responses of thalamic neurones in the rat.
作者信息
Hill R G, Pepper C M
出版信息
Br J Pharmacol. 1978 Sep;64(1):137-43. doi: 10.1111/j.1476-5381.1978.tb08650.x.
Abstract
- The effects of intravenous morphine on the firing of single sensory neurones in the thalamus of the anaesthetized rat are described. 2. Low doses (0.38 to 2.00 mg/kg) of morphine depressed the excitation of nucleus lateralis neurones produced by natural noxious stimuli but were without effect on spontaneous activity. The excitation of some of these neurones by iontophoretically applied acetylcholine or glutamate was also depressed by morphine. These effects were reversed by intravenous (0.25 to 1.17 mg/kg) but not iontophoretically applied (50 to 200 nA) naloxone. 3. Similar or higher doses of morphine (0.58 to 5.07 mg/kg) did not prevent the excitation of ventrobasal thalamic neurones by non-noxious stimuli. 4. The possibility of a direct action of intravenous morphine in the thalamus is discussed.
摘要
- 本文描述了静脉注射吗啡对麻醉大鼠丘脑单个感觉神经元放电的影响。2. 低剂量（0.38至2.00毫克/千克）的吗啡可抑制自然伤害性刺激引起的外侧核神经元兴奋，但对自发活动无影响。吗啡还可抑制离子导入乙酰胆碱或谷氨酸对其中一些神经元的兴奋作用。静脉注射（0.25至1.17毫克/千克）纳洛酮可逆转这些作用，但离子导入（50至200纳安）纳洛酮则不能。3. 相似或更高剂量（0.58至5.07毫克/千克）的吗啡不能阻止非伤害性刺激引起的腹侧基底丘脑神经元兴奋。4. 讨论了静脉注射吗啡在丘脑直接作用的可能性。
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