De Moraes S
Eur J Pharmacol. 1976 May;37(1):13-22. doi: 10.1016/0014-2999(76)90003-0.
Chronic reserpine treatment of guinea pigs during 5 days (1 mg/kg/day) induces postjunctional supersensitivity in the isolated vas deferens. It has been previously proposed that postjunctional supersensitivity occurs as a result of an ionic and/or membrane mechanism. Contrasting with previous observations in vascular smooth muscle the present results demonstrate that chronic reserpine treatment did not increase the sensitivity of the depolarized vas deferens to calcium. Experiments on drug responsiveness show that the supersensitive depolarized tissues have a greater and slower rate of loss of responsiveness than do control vasa deferentia. However, in a Ca2+-free Krebs solution responsiveness of supersensitive vasa deferentia did not differ from that of control tissues. These findings suggest that, in the guinea-pig vas deferens, reserpine-induced supersensitivity could be at least partially dependent on the increased availability of a calcium store(s) probably located at the cell membrane and/or cytoplasmic compartments.
对豚鼠进行为期5天的利血平慢性治疗（1毫克/千克/天）可诱导离体输精管出现节后超敏反应。此前有人提出，节后超敏反应是由离子和/或膜机制引起的。与先前在血管平滑肌中的观察结果相反，目前的结果表明，慢性利血平治疗并未增加去极化输精管对钙的敏感性。药物反应性实验表明，超敏去极化组织的反应性丧失速率比对照输精管更大且更慢。然而，在无钙的 Krebs 溶液中，超敏输精管的反应性与对照组织并无差异。这些发现表明，在豚鼠输精管中，利血平诱导的超敏反应可能至少部分依赖于可能位于细胞膜和/或细胞质区室的钙库可用性增加。
