Villarejo Alberto, Camacho Ana, García-Ramos Rocío, Moreno Teresa, Penas Marta, Juntas Raúl, Ruiz Juan
Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain.
Clin Neuropharmacol. 2003 May-Jun;26(3):119-21. doi: 10.1097/00002826-200305000-00004.
Pisa syndrome is a rare type of truncal dystonia. Its development is associated commonly with neuroleptic treatment, but there are rare idiopathic cases or those related to neurodegenerative disorders. Recently, an association between cholinesterase inhibitors and Pisa syndrome has been described. The authors report two patients, one with Alzheimer's disease treated with risperidone and another with Parkinson's disease who presented this kind of dystonia after donepezil initiation. In the first patient the condition resolved after discontinuation of risperidone, and in the second one the condition resolved when donepezil was withdrawn. In patients with pharmacologic or degenerative dopaminergic neurotransmission disorders, cholinergic excess may induce this peculiar type of dystonia.
Pisa综合征是一种罕见的躯干肌张力障碍。其发生通常与抗精神病药物治疗有关，但也有罕见的特发性病例或与神经退行性疾病相关的病例。最近，已有胆碱酯酶抑制剂与Pisa综合征之间关联的报道。作者报告了两名患者，一名患有阿尔茨海默病且正在接受利培酮治疗，另一名患有帕金森病，在开始使用多奈哌齐后出现了这种肌张力障碍。在第一名患者中，停用利培酮后病情缓解；在第二名患者中，停用多奈哌齐后病情缓解。在患有药物性或退行性多巴胺能神经传递障碍的患者中，胆碱能亢进可能诱发这种特殊类型的肌张力障碍。
