喹硫平缓解帕金森病患者的 Pisa 综合征。
Quetiapine Relieved Pisa Syndrome in Patient With Parkinson Disease.
机构信息
Department of Neurology.
Pharmacy of Neurology, Weihai Municipal Hospital, Weihai, Shandong, China.
出版信息
Clin Neuropharmacol. 2020 Nov/Dec;43(6):171-174. doi: 10.1097/WNF.0000000000000416.
OBJECTIVES
The aim of the study was to report quetiapine-relieved Pisa syndrome in a patient with Parkinson disease and to discuss the pathogenesis and treatment of Pisa syndrome.
METHODS
We report a 74-year-old female patient with a history of Parkinson disease for 7 years. Pisa syndrome, lateral deviation of the spine and leaning to one side, appeared more than a year ago; adjusting levodopa was ineffective. After treatment with quetiapine for visual hallucinations, the patient's right side tilt was completely relieved after taking the drug for 1 month.
CONCLUSIONS
Drug-related Pisa syndrome may be associated with the imbalance in dopamine-choline. Pisa syndrome may have similar mechanisms and treatment options to dystonia.This is the first report of quetiapine relieving Pisa syndrome in a patient with Parkinson disease.
目的
本研究旨在报告一例帕金森病患者在使用喹硫平后缓解的 Pisa 综合征，并讨论 Pisa 综合征的发病机制和治疗方法。
方法
我们报告了一例 74 岁女性帕金森病患者，病史 7 年。1 年多前出现 Pisa 综合征，脊柱向一侧倾斜和倾斜；调整左旋多巴无效。在因视幻觉使用喹硫平治疗后，患者服药 1 个月后右侧倾斜完全缓解。
结论
与多巴胺-胆碱能失衡相关的药物性 Pisa 综合征可能与迟发性运动障碍的机制和治疗选择相似。这是首例帕金森病患者使用喹硫平缓解 Pisa 综合征的报告。
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