Serretti Alessandro, Cusin Cristina, Cristina Silvano, Lorenzi Cristina, Lilli Roberta, Lattuada Enrico, Grieco Gaetano, Costa Alfredo, Santorelli Filippo, Barale Francesco, Smeraldi Enrico, Nappi Giuseppe
Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy.
Psychiatr Genet. 2003 Jun;13(2):121-6. doi: 10.1097/01.ypg.0000056172.32550.f9.
The aim of the present study was to investigate tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 genes in mood disorders using a family-based association approach.
The sample included 134 nuclear mood disorder families, with subjects affected by bipolar disorder (n=103) or major depressive disorder (n=58). All subjects were genotyped using polymerase chain reaction techniques.
No significant transmission disequilibrium was found in the overall sample for any polymorphism. Analysis considering bipolar subjects only, or psychopathology traits as affection status did not influence the observed results.
The study could not support the involvement of tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.
本研究旨在采用基于家系的关联研究方法，调查酪氨酸羟化酶、儿茶酚-O-甲基转移酶和沃尔夫勒姆综合征1基因与心境障碍的关系。
样本包括134个核心心境障碍家系，其中受双相情感障碍影响的受试者有103名，受重度抑郁症影响的受试者有58名。所有受试者均采用聚合酶链反应技术进行基因分型。
在整个样本中，未发现任何多态性存在显著的传递不平衡。仅考虑双相情感障碍受试者或把精神病理学特征作为患病状态进行分析，均未影响观察结果。
该研究不支持酪氨酸羟化酶、儿茶酚-O-甲基转移酶和沃尔夫勒姆综合征1基因多态性与心境障碍有关。
