Serretti A, Macciardi F, Cusin C, Verga M, Pedrini S, Smeraldi E
Istituto Scientifico H San Raffaele, Department of Neuroscience, University of Milano School of Medicine, Italy.
Mol Psychiatry. 1998 Mar;3(2):169-74. doi: 10.1038/sj.mp.4000373.
We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH2 allele (chi 2 = 8.30, d.f. = 1; P = 0.004) and lack of the TH1 allele (chi 2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.
