[3H]麦角酸二乙酰胺在Wistar大鼠和Gunn大鼠中的胆汁排泄。
The biliary excretion of [3H] lysergic acid diethylamide in Wistar and Gunn rats.
作者信息
Back D J, Singh J K
出版信息
Experientia. 1976 May 15;32(5):616-7. doi: 10.1007/BF01990195.
PMID:1278313
Abstract
The biliary excretion of [3H] LSD was studied in Wistar and homozygous Gunn rats. In Wistar rats approximately 46% of the given dose was recovered from bile in 2.5 h whilst in the homozygous Gunn rat 26% was recovered in the same time period. In both strains the main metabolites were glucuronides.
摘要
研究了[3H]麦角酸二乙酰胺（LSD）在Wistar大鼠和纯合子Gunn大鼠中的胆汁排泄情况。在Wistar大鼠中，给药剂量的约46%在2.5小时内从胆汁中回收，而在纯合子Gunn大鼠中，同一时间段内回收了26%。在这两种品系中，主要代谢产物都是葡萄糖醛酸苷。
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