Jang Thomas L, Schaeffer Anthony J
Department of Urology, Northwestern University Medical School, Tarry 11-715, 303 East Chicago Avenue, Chicago, Illinois 60611-3008, USA.
World J Urol. 2003 Jun;21(2):95-9. doi: 10.1007/s00345-003-0335-2. Epub 2003 May 29.
There is substantiating evidence to support the role of the immune system in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Inflammation of the prostate is mediated through the cytokine-induced expression of several factors such as chemokines, inducible nitric oxide synthase, and cyclooxygenase-2. The balance between the effects of proinflammatory and anti-inflammatory cytokines determines the outcome of the inflammatory process. Several proinflammatory and anti-inflammatory cytokines have been identified in CPPS patients, their roles characterized, and their inter-relationships defined. Study of this system will provide further insights into the etiology of CP/CPPS, and lead the way for the development of novel therapeutic approaches for this morbid condition.
有确凿证据支持免疫系统在慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）发病机制中的作用。前列腺炎症是通过细胞因子诱导多种因子的表达介导的，如趋化因子、诱导型一氧化氮合酶和环氧化酶-2。促炎细胞因子和抗炎细胞因子作用之间的平衡决定了炎症过程的结果。在CPPS患者中已鉴定出几种促炎和抗炎细胞因子，明确了它们的作用，并确定了它们之间的相互关系。对该系统的研究将为深入了解CP/CPPS的病因提供进一步的见解，并为开发针对这种疾病的新治疗方法指明方向。
