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丁苯那嗪治疗小儿重度舞蹈症

Tetrabenazine in the treatment of severe pediatric chorea.

作者信息

Chatterjee Anjan, Frucht Steven J

机构信息

Department of Neurology, Columbia-Presbyterian Medical Center, New York, New York, USA.

出版信息

Mov Disord. 2003 Jun;18(6):703-6. doi: 10.1002/mds.10427.

DOI:10.1002/mds.10427
PMID:12784277
Abstract

Tetrabenazine (TBZ) is widely used to treat adults with hyperkinetic movement disorders; however, published experience with the drug in pediatric patients is limited. We report on 5 children with severe chorea who were treated with TBZ. TBZ effectively controlled chorea in 4 patients, and despite the need for relatively high doses, it was well tolerated.

摘要

丁苯那嗪(TBZ)被广泛用于治疗患有运动亢进性运动障碍的成人;然而,关于该药物在儿科患者中的应用经验报道有限。我们报告了5例接受丁苯那嗪治疗的重度舞蹈症患儿。丁苯那嗪有效控制了4例患者的舞蹈症,尽管需要相对较高的剂量,但耐受性良好。

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引用本文的文献

1
-Associated Movement Disorder.- 相关性运动障碍。
Mov Disord Clin Pract. 2016 Mar 11;3(6):615-617. doi: 10.1002/mdc3.12344. eCollection 2016 Nov-Dec.
2
Tetrabenazine: Spotlight on Drug Review.丁苯那嗪:药物审评聚焦
Ann Neurosci. 2016 Sep;23(3):176-185. doi: 10.1159/000449184. Epub 2016 Sep 9.
3
Pediatric movement disorders.小儿运动障碍
Pediatr Rev. 2015 Mar;36(3):104-15; quiz 116, 129. doi: 10.1542/pir.36-3-104.
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Update on the Non-Huntington's Disease Choreas with Comments on the Current Nomenclature.非亨廷顿舞蹈病的最新进展及对当前命名法的评论
Tremor Other Hyperkinet Mov (N Y). 2012;2. doi: 10.7916/D89P30CS. Epub 2012 Jan 30.
5
Tourette's syndrome and role of tetrabenazine: review and personal experience.抽动秽语综合征与丁苯那嗪的作用:综述及个人经验
Clin Drug Investig. 2008;28(7):443-59. doi: 10.2165/00044011-200828070-00006.
6
Chorea and related disorders.舞蹈病及相关疾病
Postgrad Med J. 2004 Sep;80(947):527-34. doi: 10.1136/pgmj.2004.019356.