Fusco Francesca Romana, Pompa Alessandra, Bernardi Giorgio, Ottaviani Fabrizio, Giampà Carmela, Laurenti Daunia, Morello Maria, Bernardini Sergio, Nuccetelli Marzia, Sabatini Umberto, Paolucci Stefano
Santa Lucia Foundation IRCCS Hospital, Department F and Laboratory of Neuroanatomy, Santa Lucia Foundation IRCCS at the European Center for Brain Research, Rome, Italy.
J Child Neurol. 2010 May;25(5):614-5. doi: 10.1177/0883073809355824. Epub 2010 Mar 5.
PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) is a rare clinical syndrome characterized by the presence of tics, Tourette syndrome, obsessive-compulsive disorder, or chorea in the context of an immediately precedent streptococcal infection. In this report, we describe the case of an 11-year-old boy who developed PANDAS with severe choreic movements. The criteria for PANDAS diagnosis were met. Moreover, serum antibrain antibodies were present. The patient was initially treated with tetrabenazine 12.5 mg twice daily with remission of the neurological symptoms. Subsequently, the patient underwent tonsillectomy and has been asymptomatic since, with antistreptolysin O titer levels in range.
PANDAS（小儿自身免疫性神经精神障碍伴链球菌感染）是一种罕见的临床综合征，其特征为在前驱链球菌感染后出现抽动、抽动秽语综合征、强迫症或舞蹈症。在本报告中，我们描述了一名11岁男孩患PANDAS并伴有严重舞蹈样动作的病例。该病例符合PANDAS诊断标准。此外，血清抗脑抗体呈阳性。患者最初接受了丁苯那嗪治疗，每日两次，每次12.5毫克，神经症状缓解。随后，患者接受了扁桃体切除术，此后一直无症状，抗链球菌溶血素O滴度水平正常。
